Quick summary

Type of medicine

Natural progestogen (micronised progesterone), used as part of combined hormone replacement therapy (HRT).

Works by

Utrogestan contains natural micronised progesterone, a hormone identical to that produced by the female body. It works by protecting the lining of the uterus (endometrium) from the stimulatory effects of oestrogens during hormone replacement therapy (HRT) with Oestrogel. This helps prevent endometrial hyperplasia and reduces the risk of endometrial cancer, while restoring a more natural hormonal balance.

Active ingredient

Progesterone (micronised)

Effective within

Utrogestan works immediately to protect the lining of the womb during your HRT cycle. However, for the relief of general menopausal symptoms (as part of your combined HRT regime), it may take 3 months to feel the full benefits of hormonal balance.

Generic?

No

Side effects

The most common side effect is drowsiness or dizziness (somnolence), which is why bedtime dosage is recommended. Other side effects may include breast tenderness, changes in menstrual bleeding (spotting), or mild headaches. Warning: If you experience sudden chest pain or difficulty breathing, seek medical help, although the risk of blood clots with body-identical progesterone is considered lower than with synthetic alternatives.

Medication details

Description

Utrogestan is a premium Hormone Replacement Therapy (HRT) containing micronised progesterone. Unlike synthetic progestogens, Utrogestan is "body-identical," meaning its chemical structure is identical to the progesterone naturally produced by your ovaries.

It is prescribed to women who still have their womb (uterus) and are taking an oestrogen supplement (like Oestrogel or patches). Taking oestrogen alone can thicken the womb lining; Utrogestan is added to shed this lining safely and prevent serious complications. Because it can cause mild drowsiness, many women find it helps improve sleep when taken at bedtime.

Ingredients

Progesterone (micronised) 100 mg. Excipients: Soya lecithin, gelatin, glycerol, titanium dioxide (E171). Allergy Warning: Contains soya lecithin. Do not use if you are allergic to soya or peanuts.

Side effects

Drowsiness, fatigue, bloating, nausea, or breast tenderness.
Less commonly: headaches, mood changes, light vaginal bleeding, or dizziness.
These effects are usually mild and temporary, especially at the start of treatment.

Warnings

Do not use this medicine if you are allergic to progesterone, if you have severe liver impairment, a history of venous thrombosis or pulmonary embolism, or unexplained vaginal bleeding. This medication may cause drowsiness, so it is recommended to take it in the evening before bedtime. Contact your doctor immediately if you experience jaundice, visual disturbances, severe headaches, or pain in the legs or chest.

Frequently Asked Questions

What should I do if I forget to take a capsule?

If you forget to take your capsule at bedtime, do not take it the next morning, as this may cause drowsiness during the day. Simply skip the missed dose and take your next capsule at the usual time the following night. Never take a double dose to make up for a forgotten one.

Will I get a period while taking this?

It depends on how you take it. If you take it cyclically (e.g., usually days 15–26 of your cycle), you will likely have a "withdrawal bleed" similar to a period after you finish the capsules each month. If you take it continuously (every day), you normally do not bleed, though some spotting can occur in the first few months.

Can I take this if I have a peanut or soy allergy?

Strictly No. Utrogestan capsules contain soya lecithin. If you are allergic to soya or peanuts, you must not take this medicine. Please inform our doctors so an alternative progesterone treatment can be prescribed.

Why do I need to take this if I am using Oestrogel?

If you still have your womb (uterus), taking oestrogen alone causes the lining of the womb to build up, which increases the risk of uterine cancer. Utrogestan acts as the "counterbalance" to keep the lining thin and healthy. If you have had a hysterectomy, you typically do not need Utrogestan.

Does this protect against pregnancy?

No. Although progesterone is used in contraceptive pills, Utrogestan prescribed for HRT is not a contraceptive. If you are under 50 or still fertile, you must use non-hormonal contraception (like condoms) to prevent pregnancy.

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